Recognition, diagnosis, and early management of suspected sepsis: summary of updated NICE guidance

What you need to knowCalculate NEWS2 scores to determine an adult’s risk of severe illness or death from sepsis in acute hospital, mental health, and ambulance settingsUse the person’s risk level to help determine the time window in which to give antibioticsSepsis is defined as life threatening organ dysfunction caused by a dysregulated host response to infection.1 In 2016, the National Institute for Health and Care Excellence (NICE) first published guidance on recognising, diagnosing, and managing suspected sepsis. In May 2022, a statement published by the Academy of Medical Royal Colleges2 (and endorsed by NHS England) on use of the updated National Early Warning Score (NEWS2)3 sought to guide the urgency of antibiotic prescribing and source control. The statement was based on a narrative review of the literature and expert clinical consensus.As a result, in January 2024, NICE guidance was updated to include NEWS2 for stratifying risk of severe illness…
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