TAVI for severe aortic stenosis … and other research

TAVI for severe aortic stenosis and low surgical riskA randomised controlled trial compared transcatheter aortic valve implantation (TAVI) with surgical aortic valve replacement (SAVR) in people with severe, symptomatic aortic stenosis and a low surgical risk. The multicentre study set in Germany is the first to do so without industry funding. The rates of death from any cause or fatal or non-fatal stroke at one year were lower in those randomised to TAVI (5.4%) compared with SAVR (10.0%) (hazard ratio 0.53, 95% confidence interval 0.35 to 0.79). Although the long term outcomes are still uncertain, an effective treatment that avoids surgery and has a faster recovery time would seem a more appealing option for patients, and may explain why 13.4% of participants randomised to SAVR crossed over or dropped out (9.8% and 3.6% respectively), compared with only 2.3% in the TAVI arm of the study.N Engl J Med doi:10.1056/NEJMoa2400685Aspirin fails…
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