SSRIs and anticoagulants . . . and other stories

Selective serotonin reuptake inhibitors and oral anticoagulantsSSRIs are among the most frequently prescribed antidepressants, at least in part because of their favourable safety profile. However, serotoninergic mechanisms are involved in haemostasis, and the potential adverse effects of these drugs may have been underestimated. A study used a UK primary care database to compare the risk of major bleeding in people already taking SSRIs who were starting oral anticoagulants because of atrial fibrillation with controls using oral anticoagulants alone. Risk of bleeding increased by 33% in the first few months for people taking both SSRIs and oral anticoagulants (JAMA Netw Open doi:10.1001/jamanetworkopen.2024.3208).Mixed connective tissue diseaseA retrospective study in France which reviewed 300 patients who fulfilled criteria for mixed connective tissue disease reveals the variability of the prognosis. Over a median follow-up of eight years, nearly half achieved remission. On the other hand, a third progressed to interstitial lung disease or pulmonary…
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