Tom Nolan’s research reviews—22 June 2023

Lemons, limes, and fluKey lemon pie? Lime meringue? I’ve been trying all week to think of recipes where you could swap the lemons for limes, or vice versa, and still have a tasty bite to eat. In 2014, Sally Davies, England’s chief medical officer at the time, argued that you couldn’t judge the benefits of oseltamivir in pandemic flu based on studies of oseltamivir in seasonal flu as they were “a bit like lemons and limes. They are both citrus fruits and you can use them for the same recipes, but they are different.” She was referring to the conclusions of a Cochrane review that found no good evidence to support claims that oseltamivir reduced hospital admissions when given for seasonal influenza. Nine years later, a new systematic review and meta-analysis of outpatients with confirmed influenza asked to take oseltamivir or placebo or a nonactive control concludes, once again, that:…
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