Cerebral regional tissue Oxygen Saturation to Guide Oxygen Delivery in preterm neonates during immediate transition after birth (COSGOD III): multicentre randomised phase 3 clinical trial

This paper by Pichler and colleagues (BMJ 2023;380:e072313, doi:10.1136/bmj-2022-072313, published 24 January 2023) has been corrected in several places.Readers Kanekal Gautham, Brian King, and Atul Malhotra submitted a rapid response and contacted The BMJ’s editorial team with concerns that some sentences in the paper overstated the findings of the study. Based on these comments, the authors and the editorial team have removed the following three sentences from the “What this study adds” box, discussion, and conclusion of the original paper.What this study adds“Although the results for mortality were not statistically significant, the overall 1.3% reduction in deaths (12/304 (4.0%) in the near infrared spectroscopy group v 16/303 (5.3%) in the control group) could potentially result in more than 14 000 additional survivors from the estimated 1.1 million infants <37 weeks’ gestation who die annually”.Discussion“Although the results of our study were not statistically significant, the overall 1.3% reduction in deaths could... Read Original Article: Cerebral regional tissue Oxygen Saturation to Guide Oxygen Delivery in preterm neonates during immediate transition after birth (COSGOD III): multicentre randomised phase 3 clinical trial »