Tom Nolan’s research reviews—3 November 2022

Taking the pressure off after a strokeIt seems that aggressive—sorry “intensive”—blood pressure targets in the hours after endovascular thrombectomy for acute ischaemic stroke may not be such a good idea. An open-label study across 44 hospitals in China randomised 821 patients with raised systolic blood pressure (≥140 mm Hg) after successful reperfusion for acute ischaemic stroke. They were allocated to either a target blood pressure of <120 mm Hg to be achieved within an hour and sustained for 72 hours or a more relaxed target of 140-180 mm Hg. The study was stopped early when an interim review of outcomes found that those receiving the intensive blood pressure management had more early neurological deterioration (odds ratio 1.53 (95% confidence interval 1.18 to 1.97)) and major disability at 90 days (OR 2.07 (1.47 to 2.93)).Lancet doi:10.1016/S0140-6736(22)01882-7Agonising over the next new drug to treat diabetes and obesityThe 2022 prize for the drug... Read Original Article: Tom Nolan’s research reviews—3 November 2022 »