10 key questions about monkeypox the world needs to answer

Just over three months ago, public health authorities in the U.K., Europe, and the U.S. began to sound the alarm on the arrival of monkeypox. Since then, this long-neglected tropical disease — which until this year was mostly limited to periodic spillovers in the areas of Western and Central Africa where the virus is endemic — has gone global. As of Aug. 26, 100 countries had reported nearly 47,000 cases, according to the World Health Organization.

The explosive epidemic has caught governments off-guard and sent scientists scrambling to better understand the orthopoxvirus causing it.

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