Drug May Prevent Migraine Pain Before Headache Starts

A medication called ubrogepant may help people avoid or greatly minimize headache symptoms and experience fewer limitations on their daily activities if the drug is taken when the first signs of a migraine develop, according to a study published recently in the journal Neurology. Ubrogepant is a calcitonin gene-related peptide receptor antagonist, also called a CGRP inhibitor. CGRP is a protein involved in the migraine process. In a study of more than 500 adults who experienced migraine headaches for at least a year and had two to eight migraine attacks per month during the three months prior to the start of the study, all of the participants could identify signs that a migraine would be starting within a few hours. About 65 percent of the people who took ubrogepant reported feeling “not at all limited” in their daily activities or “a little limited,” compared with 48 percent of the study participants who took a placebo. For individuals who can reliably predict when a migraine episode is pending, ubrogepant may be an appropriate medication to ward off debilitating migraine pain and discomfort. Talk with your doctor about whether the drug could be safe and effective for you.

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