Spotlight on Supplements: Shark Cartilage

Globally, the continued increase of the bone and joint supplement market is attributed to our aging population and related issues. As we age, inflammation and the breakdown of cartilage can contribute to the development of osteoarthritis, pain, and disability in older adults. Over-the-counter supplements, such as chondroitin sulfate, glucosamine, and cartilage, from a variety of sources, are touted as potential preventative measures. EN focuses on one such product, shark cartilage, and examines the usefulness and safety of this unique supplement.

Overview. Shark cartilage powder, sourced from cartilage from the fins of hammerhead sharks or spiny dogfish, is commonly promoted as a therapy for arthritis, psoriasis, and also cancer. Commercial shark cartilage is a popular and controversial dietary supplement available in oral capsule and powder forms in various doses (often 750 milligrams). Shark cartilage gained popularity as a supplement in the 1970s due to claims that sharks avoid cancer. While these claims were since disproven, it sparked interest in potential antiangiogenic properties of shark cartilage. So, since cartilage is a bodily tissue where no blood vessels are present, it was thought that molecules isolated from shark cartilage may inhibit blood vessel growth in tumors.

Evidence. Unfortunately, to date, there is no clinical data to support that shark cartilage is effective in treating cancer, including breast, colon, lung, prostate, and brain cancer. Additionally, the efficacy of shark cartilage in supporting joint health is uncertain, as there is a lack of sufficient reliable information and the potential health risks linked with long-term use are not adequately assessed. This is not to say that cartilage-derived supplements such as collagen may not be beneficial for joint health. In data not specific to shark cartilage, a 2019 meta-analysis of randomized placebo-controlled trials found that collagen supplements may significantly decrease osteoarthritis stiffness.

Safety and Interactions. Oral shark cartilage supplements are reported as safe for most individuals with short-term use, though there is limited data to support this claim. While rare, side effects of supplementation may include nausea, vomiting, GI upset, or a poor taste in the mouth. Shark cartilage may stimulate the immune system, so individuals with auto-immune disorders should avoid use. This supplement also contains calcium. People with hypercalcemia (elevated calcium levels) should use caution. Shark cartilage may interact with other medicines, including antibiotics, immunosuppressants, and diabetes medicines. Please consult your doctor before starting a new diet or supplement regimen.

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