C difficile and antibiotics . . . and other stories

Clostridioides difficile infection after antibiotic exposureA case-control study from the US quantified the risk of Clostridioides difficile infection following a recent antibiotic prescription. It found a 20-fold variation across antibiotic classes and only slightly less variation across individual antibiotics within classes. Clindamycin and later generation cephalosporins carried the greatest riskfor C difficile infection, while tetracyclines hardly increased risk at all (Open Forum Infect Dis doi:10.1093/ofid/ofad413).Loneliness and Parkinson’s diseasePeople who said they were lonely at the time of recruitment into the UK Biobank study were more likely to develop incident Parkinson disease over 15 years of observation. The association was only slightly diminished after adjustment for demographic factors, socioeconomic status, social isolation, polygenetic risk score, smoking, physical activity, body mass index, and comorbidities. Nor could it be explained by the possibility that the prodromal features of the disease led to withdrawal from social activities. Stratified by time, loneliness only became linked…
Read Original Article: C difficile and antibiotics . . . and other stories »