How the Epstein-Barr virus transforms B cells

Off Health, Health Information, Human Health, Science and Health, Science and Research, Science Daily, Uncategorized

Epstein-Barr virus (EBV) infection is known to convert resting B lymphocytes into immortal cells that continuously multiply, leading to posttransplant lymphoproliferative disorder (PTLD). Researchers have now uncovered the molecular mechanisms of this growth transformation, demonstrating the crucial role of the cancer-related gene IMPDH2 and nucleolar enlargement. Additionally, the research revealed strong evidence supporting the efficacy of mycophenolate mofetil, an approved immunosuppressant, in inhibiting PTLD, highlighting its therapeutic significance.
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