What scientists know — and don’t know — about how monkeypox spreads

The explosive trajectory of monkeypox to nearly 90 countries since the current outbreak was detected in the United Kingdom in mid-May has caught many governments off-guard, and created confusion about how monkeypox spreads from person to person.

In some ways, the virus is acting differently than it has in the past. For decades, researchers in West and Central Africa, where the virus is endemic, have observed that outbreaks there tend to be self-limiting. A single case or small cluster would pop up occasionally, caused by hunting and handling infected animals or being bitten by one, but those spillover events rarely kicked off long chains of transmission within communities.

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