Cryo-EM reveals how ‘911’ molecule helps fix damaged DNA

When something goes wrong during DNA replication, cells call their own version of 911 to pause the process and fix the problem — a failsafe that is critical to maintaining health and staving off disease. Now, scientists have for the first time revealed how a key piece of this repair process — appropriately called the 911 DNA checkpoint clamp — is recruited to the site of DNA damage. The findings illuminate new insights into the way cells ensure genetic instructions are properly passed from one generation of cells to the next.
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