Opinion: Looking back and looking ahead: Vioxx, drug safety, and the legacy of Sen. Michael Enzi

The prescription painkiller originally known as Vioxx may be making a comeback after its maker, Merck, abruptly pulled it from the market in 2004 following studies that showed the drug roughly doubled patients’ risks of heart attack and stroke and may have contributed to an estimated 60,000 deaths.

According to STAT, Tremeau Pharmaceuticals, a privately held Massachusetts drug company, is about to begin clinical trials of rofecoxib (the generic name for Vioxx) as a treatment for hemophilic arthropathy, a persistent joint disease for which doctors often prescribed Vioxx off-label.

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