Tom Nolan’s research reviews—1 February 2024

Weight loss and cancer diagnosisMost studies investigating weight loss and cancer use codes for unintended weight loss in the patient record to estimate the likelihood of a subsequent cancer diagnosis. As such, they don’t tell us how much weight loss is significant: it could be 1%, 5%, or 10%, depending on all the various different factors swirling around in the consultation. A new analysis tries to help us put a number on it, reviewing weight data in two major cohort studies of US healthcare workers and seeing how often people get diagnosed with cancer within a year of weight loss being recorded. It found that those with weight loss of greater than 10% of their body weight had an incidence of 1362 cancer cases per 100 000 person-years, compared with 869 cancer cases per 100 000 person-years in those with no weight loss. Those who seemed to have lost weight…
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