Non-steroidal anti-inflammatory drugs may disrupt muscle and tissue repair

Camacho and colleagues’ study highlights the economic and health impacts of high risk non-steroidal anti-inflammatory drug (NSAID) use.1 I would like to draw attention to the effects of NSAIDs on muscle and connective tissue repair, which is pertinent to the study.NSAIDs are widely used to manage pain and inflammation from musculoskeletal injuries. While they relieve symptoms, their impact on tissue healing is concerning. Inflammation is essential for muscle and connective tissue repair—NSAIDs, by inhibiting prostaglandins, can disrupt this process.The inflammatory phase involves satellite cell activation, necessary for muscle regeneration. Prostaglandins facilitate inflammation and promote satellite cell proliferation.23 NSAIDs, by inhibiting prostaglandins, can impair muscle regeneration, leading to decreased repair and increased fibrosis.45Connective tissues like tendons and ligaments also rely on inflammation for proper repair. Prostaglandins support collagen synthesis and remodelling, and NSAID inhibition can interfere with these processes.67 NSAIDs have been associated with delayed healing and reduced strength in tendons…
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