Vaccination doses. . . and other stories

Different arms for two dose vaccinationsAntibody responses in 900 people who received two dose vaccinations against covid-19 were about 10% greater in those whose second dose had been given in the opposite arm to the first, compared with those who had received both doses in the same arm. The difference was apparent three weeks after the second booster and persisted beyond 13 months. One possible explanation is that by giving a shot in each arm immune responses from different sets of lymph nodes are activated. However, since arm selection wasn’t randomised, unrecognised bias from, for example, vaccine batch effects might have played a part (J Clin Investig doi:10.1172/JCI176411).Masks for childrenOpinion on the benefits of wearing a mask to prevent transmission of covid-19 and other respiratory infections is divided. Evidence of effectiveness is particularly weak for children wearing masks. A systematic review identified 22 relevant investigations, none of them randomised trials….
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