Update to living systematic review on SARS-CoV-2 positivity in offspring and timing of mother-to-child transmission

This living systematic review by Allotey and colleagues (BMJ 2024; 384:067696) has been updated. For the latest update, visit doi:10.1136/bmj.2021-067696. The latest version of this living systematic review (update 1) includes 643 studies of which 343 are cohort studies and 300 case series and case reports. 2.7% of the babies born to mothers with SARS-CoV-2 infection tested positive with RT-PCR. Positivity rates varied between regions, being the highest in studies from Latin America and the Caribbean (8.5%). Severe maternal covid-19, maternal death, maternal postnatal infection, caesarean section, and preterm delivery are associated with SARS-CoV-2 positivity in offspring. Of the positive babies with data for the timing of exposure and type and timing of tests, 32 had confirmed mother-to-child transmission. The results confirm vertical transmission of SARS-CoV-2, although this is rare.
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