Efficacy and safety of tranexamic acid in acute haemorrhage

What you need to knowTranexamic acid is a synthetic haemostatic drug that inhibits fibrinolysisIt is effective in reducing bleeding and mortality, although to different extents in trauma, peripartum, and surgical settingsIt is generally safe and inexpensive with few adverse reactions, although further studies are needed to assess its safety in settings of high thromboembolic riskA 33 year old woman in the fourth month of pregnancy is referred to the emergency department because of spontaneous massive antepartum haemorrhage. On admission her haemoglobin level has dropped to 7 g/dL and she is transfused with three packed red blood cell units. Her coagulation parameters are normal but sonography of the fetus reveals a formerly unknown placenta praevia. Bleeding stops immediately after placement into the vagina of a cotton swab soaked with a 1000 mg vial of tranexamic acid. In addition, on-demand oral therapy with tranexamic acid (1000 mg every eight hours) is prescribed…
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