Future-case control crossover analysis for adjusting bias in case crossover studies

Overview of case crossover designThe case crossover study is a self-controlled, outcome anchored design to assess the association between transient exposures and acute outcomes.1 The design compares the likelihood of exposure during a hazard window (a predefined time period when exposure might cause the event) and a reference window (a predefined time period before the hazard window when exposure is less likely to cause the outcomes) in order to infer possible causality between exposure and outcome. A case crossover study usually includes a washout window between the aforementioned two windows to ensure that any effects from a previous drug exposure have been eliminated. The case crossover study has become one of the most efficient tools for drug safety assessment because it only requires groups of people who have experienced adverse events (case only design); this eliminates the need for external control populations, because patients serve as their own controls. This…
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