There is no evidence that vitamin D prevents cardiovascular events

The trial by Thompson and colleagues of the effect of vitamin D supplementation on major cardiovascular events is interesting,1 but it is a pity that the main report appears positive when the overall result was null.When put in context with all other trials of vitamin D supplementation, there is no robust evidence it lowers cardiovascular events. For example, in the Vital trial, major cardiovascular events occurred in 805 participants (396 in the vitamin D group and 409 in the placebo group; hazard ratio 0.97 (95% confidence interval 0.85 to 1.12), P=0.69).2 In the analyses of secondary end points, for death from cardiovascular causes the hazard ratio was 1.11 (0.88 to 1.40).There is also no evidence vitamin D prevents cancers or other major diseases. For now, doctors should not be advocating vitamin D supplementation for prevention of chronic disease but should continue instead to promote evidence based interventions such as lifestyle…
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