Phenotypes, cardiovascular disease . . . and other stories

Genome-wide association studies of cardiovascular diseaseAccording to the NHGRI-EBI catalogue of human genome-wide association studies (https://www.ebi.ac.uk/gwas), 1700 studies have been performed on phenotypes related to common cardiovascular diseases, such as coronary artery disease, atrial fibrillation, stroke, and hypertension. Hundreds of genomic loci associated with these phenotypes have been identified. Although polygenic scores that summarise the aggregate effect of these genetic variants have the potential to improve risk stratification for individuals, they haven’t yet made much impact in clinical care (Physiol Rev doi:10.1152/physrev.00024.2022).Preventing post thrombotic syndromeLower limb pain and swelling are common long term complications of deep venous thrombosis and, once established, they are hard to treat. A systematic review reckons that wearing elastic compression stockings gives a worthwhile reduction in the chances of developing post thrombotic syndrome. However, wearing stockings had no effect on rates of recurrent deep venous thrombosis or on mortality (Thromb Res doi:10.1016/j.thromres.2023.03.016).The microbiology of atherosclerosisA cross-sectional…
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