Tom Nolan’s research reviews—1 December 2022

Waiting for the next confidence intervalMany of the terms used in research papers seem ripe for being repurposed for clinical practice. For instance, the P value could be a measure of how likely a urine dipstick is to change management for a patient with suspected urinary tract infection (usually <0.05). A confidence interval might be the part of the day, usually lasting about 20 minutes and never occurring after 11 am, when you feel that you’re doing a decent job. Crossing the futility boundary, instead of being the point at which they stop a trial early because the drug clearly doesn’t work, could be when you realise you’re not going to leave on time so there’s no point rushing. Meanwhile, in a randomised controlled trial of pemafibrate versus placebo in over 10 000 patients with type 2 diabetes, high triglyceride levels, and low HDL cholesterol, an interim analysis found the... Read Original Article: Tom Nolan’s research reviews—1 December 2022 »