Borrowing CAR-T tool from cancer therapy, lupus patients go into remission
Rheumatology — the study of immune-system-driven diseases of the bones, joints, muscles, and in-betweens — has inherited plenty of hand-me-downs from cancer research. For example, there are ways of squelching an immune system in order to shrink certain kinds of cancerous tumors. And scientists have found that, when retrofitted, those strategies can also alleviate some symptoms of autoimmune conditions.
CAR-T therapy, a way of amplifying a person’s own immune power against a disease target, is the latest tool in this shared playbook. Half a dozen people with severe lupus have gone into remission from their disease after receiving CAR-T, a result that researchers say could usher in a new era for a whole suite of hard-to-treat autoimmune conditions.
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