Covid hasn’t given up all its secrets. Here are 6 mysteries experts hope to unravel

For a formidable adversary with plenty of secrets up its sleeve, the coronavirus presented one bright bull’s-eye for the world’s response. Scientists, in record time, developed vaccines based on the virus’s spike protein that in turn have saved millions of lives.

Yet more than two years after SARS-CoV-2 appeared, as documented deaths in the U.S. near 1 million and estimated global deaths reach as high as 18 million, there are still many mysteries about the virus and the pandemic it caused. They range from the technical — what role do autoantibodies play in long Covid? Can a pan-coronavirus vaccine actually be developed? — to the philosophical, such as how can we rebuild trust in our institutions and each other? Debate still festers, too, over the virus’s origins, despite recent studies adding evidence that it spilled over from wildlife.

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