How a two-faced molecule can silence problematic genes

Researchers have developed a technology, heteroduplex oligonucleotide (HDO), that silences certain genes whose high expression levels fuel disease. Adding a specific molecular tag allowed them to target the HDO to immune cells called lymphocytes safely and efficiently. Doing so with an HDO specific to a gene called Itga4 improved symptoms in a mouse model of multiple sclerosis, suggesting this technology may be developed to use in human immune disorders.
Read Original Article: How a two-faced molecule can silence problematic genes »