How much naloxone is needed to reverse an opioid overdose? New high-dose treatments are raising questions 

At a time when a record number of Americans have died from drug overdoses — with the vast majority involving opioids — the recent approval of two new forms of naloxone, a drug that reverses opioid overdoses, would seem to be welcomed.

Instead, the medicines are opening a fierce debate over whether they could make matters worse.

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