Listen: The decade in breakthrough drugs, the year in bad CEOing, and the viruses that cure disease

Which drug defined the decade? Who’s the worst CEO in biopharma? And how does gene therapy actually work?

We discuss all that and more on the latest episode of “The Readout LOUD,” STAT’s biotech podcast. First, STAT’s Matthew Herper joins us to discuss the most important drugs of the past decade, including treatments for hepatitis C, cystic fibrosis, and cancer. Then, we delve into the holiday tradition that is voting on the best and worst CEOs in biotech. Later, science journalist Karen Weintraub dials in to explain the crucial but little-discussed technology that makes gene therapy work. Finally, the podcast gets self-indulgent as we bid farewell to senior producer Matthew Orr by subjecting him to a lightning round.

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