Monkeypox: New clinical symptoms are identified in confirmed cases

The largest study of confirmed monkeypox cases to date has identified new clinical symptoms that are similar to those of syphilis and other sexually transmitted infections and could easily lead to misdiagnosis.1 These symptoms included single genital lesions and sores on the mouth or anal mucosa.An international collaboration across 16 countries reported 528 infections that were diagnosed between 27 April and 24 June 2022. In the study, published in the New England Journal of Medicine, 95% of these patients presented with a rash, 73% had anogenital lesions, and 41% had mucosal lesions.A 10th of the patients (54) had only a single genital lesion. Another unexpected finding was that 15% had anal or rectal pain (or both).The study authors said that the current case definitions for monkeypox should be expanded to help diagnosis and slow the spread of infection. Existing definitions do recommend consideration of monkeypox in the context of any…
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