Priscilla Chan charts an ambitious, unglamorous course to fight disease. (Her husband is involved, too.)

SAN FRANCISCO — Dr. Priscilla Chan was just over a year out of her pediatric residency when, in 2016, she took the stage beside her spouse, Facebook founder Mark Zuckerberg, and pledged to affirmatively answer the question projected on the big screen behind them: “Can we cure all diseases in our children’s lifetime?”

It was the sort of absurdly ambitious question that would be easy to dismiss from a Silicon Valley technologist — the billionaire instantly recognizable in his gray T-shirt and jeans. But Chan, who grew up in the Boston suburbs, knew something about science. She had studied biology and worked in a neuroscience lab. She knew that the human body was more complicated than the most dizzyingly technical challenges her husband had overcome.

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