Newsbriefs: Exercise for Memory; Proton Pump Inhibitors; SCC

Exercising Twice Per Week Can Help Improve Memory.

The American Academy of Neurology (ANN) has updated its clinical practice guidelines to recommend that people with mild cognitive (MCI) impairment engage in regular exercise. While there is no “high-quality” evidence that supports treatment of MCI using drugs, regular exercise training may improve cognitive measures, the AAN panel recommended. The risk of developing MCI, a condition associated with problems with memory and thinking, increases with age. While there is strong evidence that MCI can progress to dementia, not everyone who has MCI will go on to develop dementia. The AAN says that people aged 65 and older who have MCI have a 7.5 percent risk of developing dementia in the first year after diagnosis; by year three, the risk rises to about 20 percent. People with MCI may struggle to finish complex tasks and fully grasp information they have read, while people with dementia struggle with daily tasks such as eating, bathing, and getting dressed. Sometimes symptoms similar to MCI manifest, such as depression, medication side effects, or disturbed sleep; it is important to meet with your doctor to determine the root cause, said lead author and AAN Fellow Dr. Ronald C. Petersen, Mayo Clinic, Rochester, MN.

Proton Pump Inhibitors Linked to Dementia Risk.

A recent study of 774,000 participants age 75 and older and free of dementia at baseline showed that the patients receiving a proton pump inhibitor (PPI) medication had a significantly increased risk of incident dementia compared with the patients not receiving a PPI medication. Researchers concluded that avoiding PPI medications may prevent dementia development. Findings were published in JAMA Neurology/The JAMA Network, January 2018.

Reduce Risk of Squamous Cell Carcinoma.

Topical fluorouracil 5% applied twice a day to the face and ears for up to four weeks reduced the risk of squamous cell (SCC) carcinoma requiring surgery by 75 percent in the first year after use, according to a study published online Jan. 3, 2018 in JAMA Dermatology. Researchers noted a 49 percent reduction in those requiring Mohs surgery treatments for basal cell carcinomas and keratinocyte carcinomas in year two following fluorouracil treatment.

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